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My Research Group - The Systems Inflammation Group Infectious diseases and inflammatory disorders are major contributors to the global burden of disease, thereby having a huge socio-economic impact. Decades of research have unraveled the arsenal of mechanisms by which the host immune system detects an invading microbe and elicit an innate immune response ensuring clearance of the pathogen while exerting a minimal damage to the host.
Any failure in this chain could lead to chronic diseases such as Atherosclerosis; as well as devastating conditions like sepsis and sepsis-induced death. It is critical for the host to restore homeostasis and resolve the inflammation upon microbial infections through a collective and meticulous coordination of a number of controlled molecular events such as chromatin remodeling, transcription, translation and post-translational modifications PTMs.
We believe that our basic research-focused systems-level approaches would yield deeper and broader understanding of inflammatory signaling which will have enormous translational potential.
The research group currently includes 1 Ph. Positions and Employment Jun. Journal of Cell Biology. A time-resolved molecular map of the macrophage response to VSV infection. Superoxide dismutase 1 protects from interferon-mediated oxidative damage in viral hepatitis. Setdb2 mediates virus-induced susceptibility to bacterial superinfection. Towards effective sharing of high-dimensional immunology data. Protein interaction networks in innate immunity.
Viral immune modulators perturb the human molecular network by common and unique strategies. A signaling network of thyroid-stimulating hormone. Journal of Proteomics and Bioinformatics. A proteogenomic approach to map the proteome of an unsequenced pathogen - Leishmania donovani. When I read their profiles, then I know, they all were looking for future life partner. Just from watching a quick run-through of this film now being offered through Eros Now, here on Amazon, it looks like a 5 Star film.
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